EXPERIMENTS ON THE CHEMOTHERAPEUTIC EFFECT OF O-AMINOPHENOL UPON TUBERCLE BACILLI
نویسندگان
چکیده
منابع مشابه
The Effect of Spermine on Tubercle Bacilli
A crystalline substance capable of suppressing the growth of a variety of mycobacteria in vitro has been isolated from extracts of tissue in acidified dilute ethanol. This inhibitory material was found to be equally active against virulent, attenuated, and avirulent variants of human and bovine tubercle bacilli, but had little or no effect on saprophytic mycobacteria and on several non-acid-fas...
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All preparations of sphingomyelin tested, whatever the tissues from which they originated, were found to enhance the growth of tubercle bacilli in vitro. Cerebrosides were inactive in this respect. Sphingomyelin promotes growth through two independent mechanisms: (a) It neutralizes the toxicity of long chain fatty acids probably by forming with them inert complexes. This protective effect facil...
متن کاملThe Effect of Organic Acids on Mammalian Tubercle Bacilli
The growth of tubercle bacilli in vitro was inhibited by the addition of the sodium salts of very low concentrations of certain organic acids to a variety of liquid and agar culture media containing whole serum or serum albumin. Capric acid was the most active of the compounds tested, but inhibition of growth occurred also with the shorter aliphatic acids. Lactic acid was also growth-inhibitory...
متن کاملOn the nucleoproteins of avian tubercle bacilli.
The nucleic acids of tubercle bacilli have formed the subject of several studies, among which may be mentioned those by Ruppel (l), Levene (2), and Johnson and his associates (3-5). The work of Mensel and Heidelberger (6) on the fractionation of the proteins of the tubercle bacillus revealed the presence of several protein fractions, rich in phosphorus and in purines, which appeared to be nucle...
متن کاملStudies on the Virulence of Tubercle Bacilli
The bacillary cords characteristic for virulent tubercle bacilli are readily disrupted when wet bacilli are suspended in hydrocarbons such as paraffin oil or petroleum ether. The disruption of cords is due to the removal of a material coating the surface of the bacilli and causing them to adhere to each other. This material can be obtained from virulent bacilli by extracting them with petroleum...
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ژورنال
عنوان ژورنال: The Japanese Medical Journal
سال: 1948
ISSN: 1884-281X
DOI: 10.7883/yoken1948.1.422